辉瑞肺癌突破性新药Lorlatinib(劳拉替尼)表现优异有效控制脑转移

今日,辉瑞(Pfizer)公司宣布了在研新一代酪氨酸激酶抑制剂lorlatinib的2期临床试验完整数据,该药物在治疗ALK阳性和ROS1阳性的晚期非小细胞肺癌(NSCLC)患者的肺肿瘤和脑转移上显示出有临床意义的活性。Lorlatinib(劳拉替尼)有潜力成为肺癌和脑转移患者的有效多线治疗方案。     肺癌是全球癌症死亡的主要原因。NSCLC占肺癌病例的85%,转移性的NSCLC很难治疗。约75%的NSCLC患者属于转移性或晚期疾病,五年生存率只有5%。这一领域还有巨大的医疗需求未被满足。   Lorlatinib(劳拉替尼)有潜力满足这一患者群体的需求。作为一款在研、新一代ALK/ROS1酪氨酸激酶抑制剂,lorlatinib已被证明在携带ALK和ROS1染色体重排的临床前肺癌模型中具有高度活性。Lorlatinib(劳拉替尼)是专门用于抑制可以驱使肿瘤对其它ALK抑制剂耐药并穿透血脑屏障的基因突变。 ▲Lorlatinib(劳拉替尼)的分子结构式(图片来源:MedChem)   Lorlatinib(劳拉替尼)在2期临床试验中显示出对肺肿瘤和脑转移的持久的疗效。该试验包含了275名NSCLC患者,根据生物标志物(ALK阳性或ROS1阳性)和之前的治疗被归为6个队列。研究的主要终点是由独立中央审查(ICR)证实的客观缓解率(ORR)和颅内ORR(IC-ORR)。   结果显示:   • ALK阳性初治组:ORR为90%(27/30; 95% CI: 74, 98),IC-ORR为75%(6/8; 95% CI: 35, 97); • ALK阳性且先前接受过crizotinib治疗组:ORR为69%(41/59; 95% CI: 56, 81),IC-ORR为68%(25/37; 95% CI: 50, 82); • ALK阳性且先前接受过非crizotinib的ALK抑制剂治疗组:ORR为33%(9/27; 95% CI: 16, 54),IC-ORR为42%(5/12;...

LIFESTYLE

TECHNOLOGY

LATEST NEWS

Health star ratings Kellogg reveals the cereal

The model is talking about booking her latest gig, modeling WordPress underwear in the brand latest Perfectly Fit campaign, which was shot by Lachian...

SpringFest One Fashion Show at the University of Michigan

The model is talking about booking her latest gig, modeling WordPress underwear in the brand latest Perfectly Fit campaign, which was shot by Lachian...

Xbox One to launch in China this month after all

The model is talking about booking her latest gig, modeling WordPress underwear in the brand latest Perfectly Fit campaign, which was shot by Lachian...

STAY CONNECTED

219,074FansLike
0FollowersFollow
26,400SubscribersSubscribe
- Advertisement -

POPULAR ARTICLES

FCC chair accuses Verizon of throttling unlimited data to boost profits

The model is talking about booking her latest gig, modeling WordPress underwear in the brand latest Perfectly Fit campaign, which was shot by Lachian...

Creative decorating with houseplants, from floor to ceiling

The model is talking about booking her latest gig, modeling WordPress underwear in the brand latest Perfectly Fit campaign, which was shot by Lachian...

Show HN: ResMaps – See who is viewing your resume are looking

The model is talking about booking her latest gig, modeling WordPress underwear in the brand latest Perfectly Fit campaign, which was shot by Lachian...

LATEST REVIEWS

Modern Language Wars, PHP vs Python vs Ruby

The model is talking about booking her latest gig, modeling WordPress underwear in the brand latest Perfectly Fit campaign, which was shot by Lachian...